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Alexander Khoruts, MD
Alexander Khoruts, MD
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Gastroenterology (GI) Clinic
Phillips-Wangensteen Building
Clinic 1E
516 Delaware St. SE
Minneapolis, MN 55455
612-624-9709

Philosophy of Care:

A physician is first and foremost a patient advocate. The patient must feel secure that he or she is getting the best care possible, will not have to face illness alone, and will be heard and understood.

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Board Certifications:

2001 – 2003 Department of Medicine Young Investigator Award, University of Minnesota

Reinhardt R.L., Khoruts A., Merica, R., Zell, T., and M.K. Jenkins. 2001. Visualizing the generation of memory CD4 T cells in the whole body. Nature 410:101-105.

Thorstenson, K.M., and A. Khoruts. 2001. Generation of anergic and potentially immunoregulatory CD25+CD4+ T cells in vivo following induction of peripheral tolerance with intravenous or oral antigen. J. Immunol. 188-195.

Moses, C.T., Thorstenson, K.M., Jameson, S.C., and A. Khoruts. 2003. Competition for self ligands restrains homeostatic proliferation of naïve CD4 T cells. Proc. Natl. Acad. Sci. USA. 100:1185-1190.

Hagen, K., Moses, C.T., Drasler, E.F., Podetz-Pedersen, K., Jameson, S.C., and A. Khoruts. 2004. A role for CD28 in lymphopenia-induced proliferation of CD4 T cells. J. Immunol. 173:3909-3915.

Hataye, J., Moon, J.J., Khoruts, A., Reilly, C.S., and M.K. Jenkins. 2006. Naïve and memory CD4+ T cell survival controlled by clonal abundance. Science 312:114-116.

Fischer, U.B., Jacovetty, E.L., Medeiros, R.B., Goudy, B.D., Zell, T., Swanson, J.B., Shimizu, Y., Miller, M.J., Khoruts, A.*, and E. Ingulli*. 2007. MHC class II deprivation impairs CD4 T cell motility and responsiveness to antigen-bearing dendritic cells in vivo. Proc. Natl. Acad. Sci. USA 104:7181-7186. *Authors equal contributors.

Kang, J., Huddleston, S.J., Fraser, J.M., and A. Khoruts. 2008. De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR. J. Leukoc. Biol. 83:1230-1239.

Winstead, C.J., Fraser, J.M., and A. Khoruts. 2008. Regulatory CD4+CD25+Foxp3+ T cells selectively inhibit the spontaneous form of lymphopenia-induced proliferation of naive T cells. J. Immunol. 180:7305-7317.

Khoruts, A., Dicksved, J., Jansson, J.K., and Sadowsky, M.J. 2010. Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea. J. Clin. Gastroenterol. 44:354-360.

Winstead, C.J., Reilley, C.S., Moon, J.J., Jenkins, M.K., Hamilton, S.E., Jameson, S.C., Way, S.S., and Khoruts, A. 2010. CD4+CD25+Foxp3+ regulatory T cells optimize diversity of the conventional T cell repertoire during reconstitution from lymphopenia. J. Immunol., 184:4749-4760.

 
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